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1

Biotransformation of 6-thioguanine in inflammatory bowel disease patients: a comparison of oral and intravenous administration of 6-thioguanine

B Jharap, NKH de Boer, RM Vos, K Smid, A Zwiers, GJ Peters, CJJ Mulder, AJ Wilhelm, AA van Bodegraven

Journal:

British Journal of Pharmacology

Year:

2011

Language:

english

File:

PDF, 513 KB

english, 2011

2

Management of Severe Ulcerative Colitis

Narula, Neeraj, Jharap, Bindia, Colombel, Jean-Frederic

Journal:

Current Treatment Options in Gastroenterology

Year:

2015

Language:

english

File:

PDF, 2.53 MB

english, 2015

3

Infants Born to Mothers with Inflammatory Bowel Disease Exhibit Distinct Microbiome Features that Persist Up to 3 Months of Life

Hu, Jianzhong, Torres, Joana, Eisele, Caroline, Nair, Nilendra, Panchal, Hinaben J., Bao, Xiuliang, Niu, Xiaohong, Cote-Daigneault, Justin, Jharap, Bindia, Maser, Elana, Kornbluth, Asher, Legnani, Pet

Journal:

Gastroenterology

Year:

2017

Language:

english

File:

PDF, 1.20 MB

english, 2017

4

Low and adequately dosed 6-thioguanine: Not so bad after all

Nanne K. H. de Boer, Bindia Jharap, Chris Mulder, Adriaan A. van Bodegraven

Journal:

Inflammatory Bowel Diseases

Year:

2008

Language:

english

File:

PDF, 57 KB

english, 2008

5

Thiopurine therapy in inflammatory bowel disease patients: Analyses of two 8-year intercept cohorts

B. Jharap, M.L. Seinen, N.K.H. de Boer, J.R. van Ginkel, R.K. Linskens, J.C. Kneppelhout, C.J.J. Mulder, A.A. van Bodegraven

Journal:

Inflammatory Bowel Diseases

Year:

2010

Language:

english

File:

PDF, 185 KB

english, 2010

6

Safety and efficacy of the immunosuppressive agent 6-tioguanine in murine model of acute and chronic colitis

Miloslav Kverka, Pavel Rossmann, Helena Tlaskalova-Hogenova, Klara Klimesova, Bindia Jharap, Nanne K de Boer, Rene M Vos, Adriaan A van Bodegraven, Milan Lukas, Chris J Mulder

Journal:

BMC Gastroenterology

Year:

2011

Language:

english

File:

PDF, 3.04 MB

english, 2011

7

Limited stability of thiopurine metabolites in blood samples: Relevant in research and clinical practise

P. de Graaf, R.M. Vos, N.H.K. de Boer, A. Sinjewel, B. Jharap, C.J.J. Mulder, A.A. van Bodegraven, A.I. Veldkamp

Journal:

Journal of Chromatography B

Year:

2010

Language:

english

File:

PDF, 617 KB

english, 2010

8

Influence of 5-aminosalicylic acid on 6-thioguanosine phosphate metabolite levels: a prospective study in patients under steady thiopurine therapy

P de Graaf, NKH de Boer, DR Wong, S Karner, B Jharap, PM Hooymans, AI Veldkamp, CJJ Mulder, AA van Bodegraven, M Schwab

Journal:

British Journal of Pharmacology

Year:

2010

Language:

english

File:

PDF, 677 KB

english, 2010

9

Intrauterine exposure to thiopurines

B. Jharap, M.L. Seinen, A.A. van Bodegraven, N.K. de Boer

Journal:

Reproductive Toxicology

Year:

2012

Language:

english

File:

PDF, 99 KB

english, 2012

10

Prolonged thioguanine therapy is well tolerated and safe in the treatment of ulcerative colitis

Dirk P. van Asseldonk, Bindia Jharap, Dirk J. Kuik, Nanne K.H. de Boer, Barend D. Westerveld, Maurice G.V.M. Russel, Frank J.G.M. Kubben, Ad A. van Bodegraven, Chris J. Mulder

Journal:

Digestive and Liver Disease

Year:

2011

Language:

english

File:

PDF, 151 KB

english, 2011

11

502 Thiopurine Metabolite Measurements During Pregnancy in Mother and Child

Bindia Jharap, Nanne de Boer, Christien J. van der Woude, Daniel W. Hommes, Pieter C. Stokkers, Dirk J. De Jong, Bas Oldenburg, Gerard Dijkstra, Ruurd M. van Elburg, Ad A. van Bodegraven

Journal:

Gastroenterology

Year:

2008

Language:

english

File:

PDF, 72 KB

english, 2008

12

503 Alteration of Thiopurinephosphate Metabolite Levels By Aminosalicylates in IBD-Patients

Peer D. Graaf, Nanne de Boer, Bindia Jharap, Chris J. Mulder, Ad A. van Bodegraven, Matthias Schwab

Journal:

Gastroenterology

Year:

2008

Language:

english

File:

PDF, 176 KB

english, 2008

13

S1231 Predictors for Failing Thiopurine Therapy in IBD Patients; Treated At An Academic or General District Hospital

Bindia Jharap, M. Seinen, Ronald K. Linskens, Jan Kees Kneppelhout, Chris J. Mulder, Nanne de Boer, Ad A. van Bodegraven

Journal:

Gastroenterology

Year:

2008

Language:

english

File:

PDF, 102 KB

english, 2008

14

S1238 Levels of 6-Thioguanine Nucleotides Following Oral and Intravenous Administration of Relatively Low-Dosed 6-TG (0,3 mg/kg) in IBD-Patients

Bindia Jharap, Nanne de Boer, René M. Vos, Godefridus J. Peters, Bram Wilhelm, Chris J. Mulder, Ad A. van Bodegraven

Journal:

Gastroenterology

Year:

2008

Language:

english

File:

PDF, 67 KB

english, 2008

15

415 Liver Histology of IBD Patients Who are Treated With 6-Thioguanine Due to Failure of Conventional Thiopurines Reveals Very Few Cases of Nodular Regenerative Hyperplasia

Dirk P. van Asseldonk, Bindia Jharap, Nanne K. de Boer, Pieter E. Zondervan, Elisabeth Bloemena, Gijsbert den Hartog, Dik B. Westerveld, Jeroen J. Kolkman, Leopold G. Engels, Adriaan A. van Bodegraven

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 55 KB

english, 2010

16

P385 Intrauterine exposure and pharmacology of conventional thiopurine therapy in pregnant inflammatory bowel disease patients

B. Jharap, N. De Boer, C.J. van der Woude, D.W. Hommes, P. Stokkers, D. de Jong, B. Oldenburg, G. Dijkstra, B. Wilhelm, R. Van Elburg, A. van Bodegraven

Journal:

Journal of Crohn's and Colitis

Year:

2012

Language:

english

File:

PDF, 48 KB

english, 2012

17

P073 ADEQUATELY DOSED 6-TG USE IN CHRONIC INTESTINAL INFLAMMATION IS NOT ASSOCIATED WITH NODULAR REGENERATIVE HYPERPLASIA: A SERIES OF 73 LIVER BIOPSIES

B. Jharap, C.J.J. Mulder, G. den Hartog, B.D. Westerveld, L.G.J.B. Engels, D.J. de Jong, A.A. van Bodegraven, N.K.H. de Boer

Journal:

Journal of Crohn's and Colitis Supplements

Year:

2007

Language:

english

File:

PDF, 60 KB

english, 2007

18

P109 DOSE-DEPENDENT INFLUENCE OF 5-ASA ON THIOPURINE METABOLISM

N. de Boer, D. Wong, P.M. Hooymans, B. Jharap, P. de Graaf, C.J.J. Mulder, L.G.J.B. Engels, A.A. van Bodegraven

Journal:

Journal of Crohn's and Colitis Supplements

Year:

2007

Language:

english

File:

PDF, 88 KB

english, 2007

19

P075 CHEMICAL STABILITY OF THIOPURINE METABOLITES IN ERYTHROCYTES DURING 6-MERCAPTOPURINE AND AZATHIOPRINE TREATMENT

P. de Graaf, R.M. Vos, N.K.H. de Boer, A. Sinjewel, B. Jharap, A.I. Veldkamp, A.A. van Bodegraven

Journal:

Journal of Crohn's and Colitis Supplements

Year:

2007

Language:

english

File:

PDF, 60 KB

english, 2007

20

P107 PREDICTORS FOR FAILING THIOPURINE THERAPY IN INFLAMMATORY BOWEL DISEASE PATIENTS; TREATED AT AN ACADEMIC OR GENERAL DISTRICT HOSPITAL

B. Jharap, M. Seinen, R.K. Linskens, J.C. Kneppelhout, C.J.J. Mulder, N.K. de Boer, A.A. van Bodegraven

Journal:

Journal of Crohn's and Colitis Supplements

Year:

2008

Language:

english

File:

PDF, 73 KB

english, 2008

21

P178 THE EFFECTIVENESS OF THIOPURINE THERAPY IN INFLAMMATORY BOWEL DISEASE PATIENTS IN AN ACADEMIC AND GENERAL DISTRICT HOSPITAL SETTING

B. Jharap, M.L. Seinen, R.K. Linskens, J.C. Kneppelhout, C.J.J. Mulder, N.K. de Boer, A.A. van Bodegraven

Journal:

Journal of Crohn's and Colitis Supplements

Year:

2008

Language:

english

File:

PDF, 89 KB

english, 2008

22

P090 THIOPURINE METABOLITE MEASUREMENTS DURING PREGNANCY IN MOTHER AND CHILD

B. Jharap, N.K.H. de Boer, C.J. van der Woude, D.W. Hommes, P.C.F. Stokkers, D.J. de Jong, B. Oldenburg, G. Dijkstra, R.M. van Elburg, A.A. van Bodegraven

Journal:

Journal of Crohn's and Colitis Supplements

Year:

2008

Language:

english

File:

PDF, 72 KB

english, 2008

23

P126 ALTERATION OF THIOPURINEPHOSPHATE METABOLITE LEVELS BY 5-AMINOSALICYLATES IN THIOPURINE USING IBD-PATIENTS

P. Graaf de, N. Boerde, B. Jharap, C. Mulder, A. Bodegravenvan, M. Schwab

Journal:

Journal of Crohn's and Colitis Supplements

Year:

2008

Language:

english

File:

PDF, 113 KB

english, 2008

24

P151 LEVELS OF 6-THIOGUANINE NUCLEOTIDES FOLLOWING ORAL AND INTRAVENOUS ADMINISTRATION OF RELATIVELY LOW-DOSED 6-TG (0, 3 MG/KG) IN INFLAMMATORY BOWEL DISEASE PATIENTS

B. Jharap, N.K.H. de Boer, R.M. Vos, G.J. Peters, A.J. Wilhelm, C.J.J. Mulder, A.A. van Bodegraven

Journal:

Journal of Crohn's and Colitis Supplements

Year:

2008

Language:

english

File:

PDF, 64 KB

english, 2008

25

Letter: thiopurines during pregnancy and intrauterine exposure to metabolites

N. K. H. de Boer, B. Jharap, M. L. Seinen, A. A. van Bodegraven

Journal:

Alimentary Pharmacology & Therapeutics

Year:

2012

Language:

english

File:

PDF, 76 KB

english, 2012

26

Mo1185 No Nodular Regenerative Hyperplasia in Sequential Liver Biopsies During Tioguanine Maintenance Therapy in Inflammatory Bowel Disease Patients

Van Asseldonk, Dirk, Jharap, Bindia, de Boer, Nanne K., Verheij, Joanne, den Hartog, Gijsbert, Russel, Maurice G., Westerveld, Dik, Becx, Marco, van Nieuwkerk, Carin, Mulder, Chris J., Bloemena, Elisa

Journal:

Gastroenterology

Year:

2014

Language:

english

File:

PDF, 428 KB

english, 2014

27

Tu1066 Long-Term Follow-up of Children Exposed Intrauterine to Maternal Thiopurine Therapy During Pregnancy in Females With Inflammatory Bowel Disease

de Meij, Tim, Jharap, Bindia, Kneepkens, Corneille M., van Bodegraven, Adriaan A., de Boer, Nanne K.

Journal:

Gastroenterology

Year:

2013

Language:

english

File:

PDF, 302 KB

english, 2013

28

M2003 Low Inter-Observer Agreement on Nodular Regenerative Hyperplasia of the Liver: An European Inter-Observer Analysis

Jharap, Bindia, van Asseldonk, Dirk P., de Boer, Nanne K., Colombel, Jean-Frederic, Diebold, Joachim, Jonker, Anne M., Leteurtre, Emmanuelle, Reinisch, Walter, Vernier-Massouille, Gwenola, Wendum, Dom

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 47 KB

english, 2010

29

W1099 Adequately Dosed 6-Thioguanine Is a Well Tolerated and Safe Rescue Drug in Azathioprine or 6-Mercaptopurine Intolerant IBD Patients

van Asseldonk, Dirk P., Jharap, Bindia, de Boer, Nanne, van Bodegraven, Adriaan A., Mulder, Chris J.

Journal:

Gastroenterology

Year:

2009

Language:

english

File:

PDF, 46 KB

english, 2009

30

W1110 6-Thioguanine Induces Remission and Mucosal Healing in IBD

van Asseldonk, Dirk P., Jharap, Bindia, De Boer, Nanne, Mulder, Chris J., van Bodegraven, Adriaan A.

Journal:

Gastroenterology

Year:

2009

Language:

english

File:

PDF, 104 KB

english, 2009

31

Intrauterine exposure and pharmacology of conventional thiopurine therapy in pregnant patients with inflammatory bowel disease

Jharap, B., de Boer, N. K. H., Stokkers, P., Hommes, D. W., Oldenburg, B., Dijkstra, G., van der Woude, C. J., de Jong, D. J., Mulder, C. J. J., van Elburg, R. M., van Bodegraven, A. A.

Journal:

Year:

2014

Language:

english

File:

PDF, 294 KB

english, 2014

32

Long-term follow-up of children exposed intrauterine to maternal thiopurine therapy during pregnancy in females with inflammatory bowel disease

de Meij, T. G. J., Jharap, B., Kneepkens, C. M. F., van Bodegraven, A. A., de Boer, N. K. H.

Journal:

Alimentary Pharmacology & Therapeutics

Year:

2013

Language:

english

File:

PDF, 113 KB

english, 2013

33

Dose-Dependent Influence of 5-Aminosalicylates on Thiopurine Metabolism

de Boer, Nanne K.H., Wong, Dennis R., Jharap, Bindia, de Graaf, Peer, Hooymans, Piet M., Mulder, Chris J.J., Rijmen, Frank, Engels, Leopold G.J.B., van Bodegraven, Adriaan A.

Journal:

American Journal of Gastroenterology

Year:

2007

Language:

english

File:

PDF, 347 KB

english, 2007

34

Drug Insight: pharmacology and toxicity of thiopurine therapy in patients with IBD

de Boer, Nanne KH, van Bodegraven, Adriaan A, Jharap, Bindia, de Graaf, Peer, Mulder, Chris JJ

Journal:

Nature Clinical Practice Gastroenterology & Hepatology

Year:

2007

Language:

english

File:

PDF, 358 KB

english, 2007

35

Stability of Thiopurine Metabolites: A Potential Analytical Bias

de Graaf, P., de Boer, N. K.H., Jharap, B., Mulder, C. J.J., van Bodegraven, A. A., Veldkamp, A. I.

Journal:

Clinical Chemistry

Year:

2007

Language:

english

File:

PDF, 71 KB

english, 2007

36

Su1287 Anal Neoplasia in Inflammatory Bowel Disease Is Associated With HPV and Perianal Disease

Ko, Huaibin M., Ruel, Joannie, Patil, Ninad, Roda, Giulia, Zhang, David, Jharap, Bindia, Harpaz, Noam, Colombel, Jean-Frederic

Journal:

Gastroenterology

Year:

2015

Language:

english

File:

PDF, 309 KB

english, 2015

37

Colonic telangiectasias in progressive systemic sclerosis

Jharap, B., Koudstaal, L., Neefjes-Borst, E., Van Weyenberg, S.

Journal:

Year:

2012

Language:

english

File:

PDF, 226 KB

english, 2012

38

Loss of Response to Anti-TNFs: Definition, Epidemiology, and Management

Roda, Giulia, Jharap, Bindia, Neeraj, Narula, Colombel, Jean-Frederic

Journal:

Clinical and Translational Gastroenterology

Year:

2016

Language:

english

File:

PDF, 291 KB

english, 2016

39

Anal Neoplasia in Inflammatory Bowel Disease Is Associated With HPV and Perianal Disease

Ruel, Joannie, Ko, Huaibin Mabel, Roda, Giulia, Patil, Ninad, Zhang, David, Jharap, Bindia, Harpaz, Noam, Colombel, Jean-Frédéric

Journal:

Clinical and Translational Gastroenterology

Year:

2016

Language:

english

File:

PDF, 926 KB

english, 2016

40

Reply

Jharap, Bindia, Colombel, Jean-Frederic, Sandborn, William J.

Journal:

Gastroenterology

Year:

2016

Language:

english

File:

PDF, 69 KB

english, 2016

41

Impact of Concomitant Endometriosis on Phenotype and Natural History of Inflammatory Bowel Disease

Lee, Kristen K., Jharap, Bindia, Maser, Elena A., Colombel, Jean-Frederic

Journal:

Inflammatory Bowel Diseases

Year:

2016

Language:

english

File:

PDF, 127 KB

english, 2016

42

Randomised clinical study: discrepancies between patient-reported outcomes and endoscopic appearance in moderate to severe ulcerative colitis

Jharap, B., Sandborn, W. J., Reinisch, W., D'Haens, G., Robinson, A. M., Wang, W., Huang, B., Lazar, A., Thakkar, R. B., Colombel, J.-F.

Journal:

Alimentary Pharmacology & Therapeutics

Year:

2015

Language:

english

File:

PDF, 299 KB

english, 2015

43

Effects of concomitant immunomodulators on the pharmacokinetics, efficacy and safety of adalimumab in patients with Crohn's disease or ulcerative colitis who had failed conventional therapy

Colombel, J.-F., Jharap, B., Sandborn, W. J., Feagan, B., Peyrin-Biroulet, L., Eichner, S. F., Robinson, A. M., Mostafa, N. M., Zhou, Q., Thakkar, R. B.

Journal:

Alimentary Pharmacology & Therapeutics

Year:

2016

Language:

english

File:

PDF, 678 KB

english, 2016

44

Associations of maternal obesity and excessive weight gain during pregnancy with subcutaneous fat mass in infancy

Jharap, Varsha V., Santos, Susana, Steegers, Eric A.P., Jaddoe, Vincent W.V., Gaillard, Romy

Journal:

Early Human Development

Year:

2017

Language:

english

File:

PDF, 296 KB

english, 2017

45

The Prevalence of Nodular Regenerative Hyperplasia in Inflammatory Bowel Disease Patients Treated with Thioguanine Is Not Associated with Clinically Significant Liver Disease

van Asseldonk, Dirk P., Jharap, Bindia, Verheij, Joanne, den Hartog, Gijsbert, Westerveld, Dik B., Becx, Marco C., Russel, Maurice G., Engels, Leopold G., de Jong, Dirk J., Witte, Birgit I., Mulder, C

Journal:

Inflammatory Bowel Diseases

Year:

2016

Language:

english

File:

PDF, 382 KB

english, 2016

46

OP037 Infants born to mothers with inflammatory bowel disease exhibit distinct microbiome features that persist up to 3 months of life

Torres, J., Hu, J., Eisele, C., Nair, N., Panchal, H., Bao, X., Niu, X., Côté-Daigneault, J., Jharap, B., Maser, E., Kornbluth, A., Legnani, P., George, J., Dubinsky, M., Stone, J., Chen, C.-L., Cleme

Journal:

Journal of Crohn's and Colitis

Year:

2017

Language:

english

File:

PDF, 196 KB

english, 2017

47

Thiopurines in Inflammatory Bowel Disease: new findings and perspectives

de Boer, Nanne K H, Peyrin-Biroulet, Laurent, Jharap, Bindia, Sanderson, Jeremy D, Meijer, Berrie, Atreya, Imke, Barclay, Murray L, Colombel, Jean-Frederic, Lopez, Anthony, Beaugerie, Laurent, Marinak

Journal:

Journal of Crohn's and Colitis

Year:

2017

Language:

english

File:

PDF, 905 KB

english, 2017

48

Diagnosing Nodular Regenerative Hyperplasia of the Liver Is Thwarted by Low Interobserver Agreement

Jharap, Bindia, van Asseldonk, Dirk P., de Boer, Nanne K. H., Bedossa, Pierre, Diebold, Joachim, Jonker, A. Mieke, Leteurtre, Emmanuelle, Verheij, Joanne, Wendum, Dominique, Wrba, Fritz, Zondervan, Pi

Journal:

Year:

2015

Language:

english

File:

PDF, 1.14 MB

english, 2015

49

Infants born to mothers with IBD present with altered gut microbiome that transfers abnormalities of the adaptive immune system to germ-free mice

Torres, Joana, Hu, Jianzhong, Seki, Akihiro, Eisele, Caroline, Nair, Nilendra, Huang, Ruiqi, Tarassishin, Leonid, Jharap, Bindia, Cote-Daigneault, Justin, Mao, Qixing, Mogno, Ilaria, Britton, Graham J

Journal:

Year:

2019

Language:

english

File:

PDF, 2.07 MB

english, 2019

50

Thiopurines with low-dose allopurinol (ThiLDA)—a prospective clinical one-way crossover trial

Chavoushi, S. Faraz, Jharap, Bindia, Friedrich, Philip, Smid, Kees, Peters, Godefridus J., Malingré, Mirte

Journal:

European Journal of Clinical Pharmacology

Year:

2019

Language:

english

File:

PDF, 321 KB

english, 2019

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